The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we have to and and this is what I hope the medical system will start doing in the future it's not just looking at a lipid panel but looking at things like ferritin GGT HSC RP which is high sensitivity C reactive protein which is an inflammatory marker and as we will talk about in this podcast perhaps the granddaddy of them all measures of insulin sensitivity which we might consider to be a triumvirate of fasting insulin c-peptide and maybe proinsulin
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
if your cardiologist is not doing fasting insulin, looking at your endothelial health, looking at your hs-CRP, looking at your fasting blood glucose, looking at your LP-PLA2, looking at your LP little A, probably looking at your apoB and your particle number, screening you for thyroid disease, insulin sensitivity like we talked about, and other things, that that that they they may not be getting the whole picture
On the lipoprotein side we can see most of what we want, which is the Lp , the LDL, the small ldl, I'm talking particle number, not cholesterol, and the VLDL as alluded to. On the inflammation side we can see specific and non-specific markers of inflammation. So on the non-specific side we can see things like fibrinogen, C-reactive protein. On the specific side you can see things like ox LDL, LpPLA2, ox phospholipid, those things. Very helpful. Endothelial health is the hardest thing to see but I include insulin here because I think that insulin is in and of itself actually toxic at high levels to the endothelium and James O'Keefe just recently was on a paper that looked at cardiovascular health in patients with type 1 diabetes so that they were able to actually use the insulin doses that people were using as a way to actually assess the impact on the... I can't remember if it was myocardium or endothelium. You can look at things like homocysteine.