In low-carb adapted diabetics, increased gluconeogenesis and worsened peripheral insulin sensitivity lead to persistently high blood glucose levels.

“what happened was is they drove the fatty acid oxidation they kept increasing gluconeogenesis because you need blood glucose so your liver if you don't have the blood glucose is going to make it and so they kept driving that pathway and then what eventually happened is you have this the gluconeogenesis and worse peripheral insulin sensitivity the cells are not responding to insulin and the carbohydrates just going higher and higher and higher and you're seeing this higher levels of carbohydrate long term in the bloodstream”