The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
and that that comes from a number of different areas so it could be that you've had so much so much energy stuffed into it that you that the cell doesn't want anymore it could be that the mitochondria are damaged oxidative stress inflammation
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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it could be that the mitochondria are damaged oxidative stress inflammation all these things because inflammation wants you to shift your resources elsewhere because it's assuming that there's some kind of infection you want to shift resources to the to the immune system because that's that's going to be needed to fight the infection that's where the information is assumed to be coming from and when when you're looking at sort of the stages of insulin resistance in most people it seems to start the fatso having nice insulin sensitive fat is like your buffer for metabolic disease so I everybody's like really against fat you know like they're trying to maybe they get liposuction or they try and go for like fat cell apoptosis and all this kind off don't do that because you it's gonna increase your risk of diabetes in 20 years time because that having having that fat is protective that is an Oregon fight isn't organ it's super important so so yet so this seems to start in the fat and then it kind of depends on I think the person but like some people will argue that it starts in the muscle if you're super sedentary yeah that might be the case but what it's essentially the cell saying I do not have the ability or the desire to process the nutrients that you're sending me that's what instant resistance it it's like a suitcase that's full yeah you can't pack anymore t-shirts in there yeah and that's either because the capacity is decreased right because say because there's injury to your mitochondria or and you know that directly feeds back to the instance receptor or your a fat cell and you're just like stuffed full of fat and you just can't take anymore and then you start saying oh no mass no more
when the mitochondria get overwhelmed with nutrients they say they emit they sort of put out reactive oxygen species so the same sorts of signaling molecules the same sorts of free radicals that can be produced by oxidized lipids are produced by our mitochondria in times of insulin resistance