Muscle and liver cells intentionally reduce glucose uptake when they have sufficient fatty acids available to spare glucose for the brain, kidneys, and testicles.

“and then there are some tissues in the body that do have a requirement for glucose they can't fat at that particularly certain the cells in the brain and the red blood cells so you need whatever glucose you have to be spared for those for those cells so the muscle tissue says do you know what I can run on fat so I'm just going to turn off this insulin signal and you don't need to give me any glucose because I'm sparing the glucose for the rest of the body and in that state yes you will also have elevated free fatty acids like you do in type 2 diabetes we are very low glucose so there's a completely different States this is the body and because of the role of insulin this is the body deciding where which nutrient should go because nutrient partitioning is insulins essentially its main job and that is insulin acting correctly in that state you don't have enough glucose to run all the cells in your body so the body selectively says this can run on fat this needs glucose so it's gonna be spared for those tissues but what happens is then if you give somebody a boatload of carbohydrate and they've been on on a keto diet for a long period of time those cells have still turned down the insulin signal right so you're gonna get this massive spike in blood sugar and say holy crap this guy's has insulin resistance but if you had to meet some carbohydrates for three or four days you know this is probably somebody who in that interim improve their lean particularly if they were overweight or instant resistant before you know they've improved their body composition potentially maybe lost some weight you know their metabolic health has almost certainly improved but you just need to give them some carbohydrate for them to like turn that turn that signal back on so this is its complex physiology really no whiteboard I love this conversation so what Tommy is saying I'll just try and summarize it or re regurgitate it for people in a different way and hopefully it'll become even more clear during states of low carbohydrate consumption of a diet the body does something that is natural called physiologic insulin resistance at the level of the muscle or glucose sparing is probably a better word and so what's happening there and there are studies which show that even one low-carb meal at night can do this and so pregnant women who are doing a glucose tolerance test or a glue cola the next day should not be doing a low carb meal or they can do a low carb meal if they want to but if you do if a pregnant woman does a low carb meal the night before a glucose tolerance test they can look insulin resistant the next day because that test is sort of flawed right and what's going on there is that when we increase the amount of fat in our diet and when we decrease the amount of carbohydrates there are different signals from the adipose tissue because of declining levels of insulin right? what we know is that if we don't eat carbohydrates if we eat a high if we eat a high fat low carb diet with a moderate amount of protein insulin signal drops”