Peter Attia· MD
so you give these young 20 year olds let's say screen we screen to this state probably a thousand but you get a distribution given a drink of glucose tolerance 75 grams you measure insulin and you can calculate insulin sensitivity index it's the crude index and it's kind of a bell-shaped curve and you have people in the bottom quartile who are insulin resistant by definition the top quartile then you ask why are those people in the bottom quartile insulin resistant and you measure glycogen synthesis using the methods we talked about briefly carbon nmr gives c1 glucose measure flux into glycogen and it's already down by 50 percent compared to the sensitive ones under matched insulin and glucose concentrations