Interventions like GLP1 agonists that resolve insulin resistance and lead to weight loss may modulate epigenetic clocks.

“So, if you took an individual who uh is insulin resistant and you put them on a GLP1 agonist and 3 months later they're 20 pounds lighter and their insulin resistance has has resolved, how does that change on the clock? Well, I would not be able to tell you specifically for individual clocks, but uh Dan Bellski's Dened in Pace clock is the one that repeatedly people have shown seems to be responding to interventions which is you know the two the two qualities that you want in a clock is one to be predictive and the other one to be predictive of ultimate income sort of you know life expectancy or the occurrence of disease but also So you want it to be um modulatable, responsive and many of them actually but the and and reproducible and reproducible.”