The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
what we know about ldl as i mentioned a little bit earlier is that essentially no matter what your level of ldl is either at 70 milligrams per deciliter or 150 milligrams per deciliter you can develop atherosclerosis if you are insulin resistant
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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there's no correlation between the level of LDL and the plaque burden in either of these two groups presumably in Miami Heart it's because it's also a group of people who are relatively healthy and have other proxy metrics suggesting they are insulin sensitive your group we know has low triglycerides High HDL part of this Triad that we've looked at proxy marker of insulin sensitivity
in the context of a human being that has an inflammatory milu an inflammatory quote soup with a high hscrp with a high fasting insulin with metabolic dysfunction they're going to have all the markers that Mike mentioned in the beginning that are going to be off in that type of person more LDL is going to equal more atherosclerotic plaque