Canonical insulin resistance is characterized by hyperglycemia and/or hyperinsulinemia, indicating impaired glucose disposal by muscle and/or liver.

“insulin resistance is canonically talked about in studied in a situation where an individual is either hyperglycemic which means their blood glucose in the fasting and postprandial state is elevated and or they are hyperinsulinemic meaning that they have excess insulin floating in their blood and under either or both of those circumstances that is an indicator that both muscle and/or liver are having a difficult time communicating with insulin and therefore disposing of glucose”