Insulin resistance may be an 'overflow' problem where cells are too full of glucose to accept more.

“but if it's an overflow paradigm the implication is completely different because the solution is to get rid of the some of the stuff that's in your suitcase right so if you bring it back to insulin resistance or hyperinsulinemia then the solution to try and get rid of this so-called insulin resistance is not giving more insulin because that was the problem in the first place putting those shirts in the suitcase that was the problem in the first place so putting more in is not the solution”

“this is a totally different paradigm than this sort of internal starvation paradigm because it's an overflow paradigm but it solves the problem of the central paradox that is why is this liver cell making so much new fat from glucose because it's jammed full of fat the glucose from the outside cannot go in but the liver cell is so busy trying to make new fact an oval lipogenesis that is just shoving it out the door but there's too much going in”