Individuals with familial hypercholesterolemia (FH) and high ApoB who are also insulin sensitive, have normal thyroid, and no genetic predisposition to hyperlipidemia are not directly comparable to individuals with metabolic dysfunction at the macrophage level.

“in that data those individuals that have accelerated atherosclerosis are not insulin sensitive like an individual who has a high apob but has the low fasy Insulin good thyroid values and that individual is not to be Apples to Apples compared to this person not to be Apples to Apples compared necessarily because of insulin sensitivity but because of metabolic dysfunction at the level of the macres”