Peter Attia· MD
glucose transport is not rate controlling as you know in the liver cell glucose just diffuses in through glut2 transporters and the insulin again binds the receptor same thing autophosphorylation the key intermediate there in liver is irs2 undergoes tyrosine phosphorylation use pi3 kinase just as you did in muscle akt2 and in liver what happens is you have a few things one not shown here is glucokinase translocation and that we've recently shown is probably very important for rate control getting glucose into the hepatocyte you also get activation of glycogen synthase and more glycogen synthesis and then you have this phosphorylation of foxo which is a transcriptional regulator and that then is excluded from the nucleus and then down regulates then gluconeogenesis through a transcriptional mechanism