The ACCORD ADVANCE VDT trial demonstrated that normalizing blood glucose did not yield significant benefits.

“and that was the real lesson of the accord advance via DT that was 2008 those are actually the trials that started me down this whole thinking that what we're doing is actually completely incorrect because if you remember for 2008 I've been doing this for like 18 years or 17 years and that was what we always thought right you get the blood glucose low enough or normalize it you're gonna see huge benefits but we didn't we didn't see any benefits at all and that was a huge paradigm shift”