Inflammation contributes to the transition from insulin resistance to fasting hyperglycemia.

“but you also have this component of inflammation has been described by many many individuals you get crown like structures macrophages move in they release alpha il-6 and what we were able to discern a lot of people would argue it was inflammation if you go back to the insulin resistance literature 10 20 years ago everyone was discussing inflammation circulating cytokines 10f alpha 6 resistant rbp circulating factors that were released from inflammation driving insulin resistance”