In individuals with insulin resistance, impaired wound healing at the endothelial level leads to the development of atherosclerotic plaques.

“More of that LDL more of that APO B is retained in the proteoglycans in the sub-intominal space that LDL is enriched in linoleic acid I know we're going to get to that therefore it's more likely to be oxidized and taken up by the macrophages and made into foam cells made into these fatty streaks”

“in people who have some degree of insulin resistance they're not doing wound healing well... in people who have some degree of insulin resistance that atherosclerotic plaque begins to develop because that wound healing at the level of the endothelium is not proceeding properly”

“if you have some degree of insulin resistance you are at a higher risk of atherosclerosis not because of your elevated apob because of the way those LDL particles those apob particles are retained in the arterial wall”

“More of that LDL more of that APO B is retained in the proteoglycans in the sub-intominal space that LDL is enriched in linoleic acid I know we're going to get to that therefore it's more likely to be oxidized and taken up by the macrophages and made into foam cells made into these fatty streaks”