Raising plasma fatty acids leads to increased acyl-CoAs and DAGs, followed by activation of novel PKCs which then blocks insulin action.

“found just the opposite to what randall predicted they got insulin resistance which is what he would have said but not through his mechanism he said g6p should go up we saw it go down and we saw glucose go down so it wasn't through inhibition of glycolysis as he said it's somehow interfering with the insulin activation of transport”