The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
maybe LDL is only a problem if you have metabolic syndrome or insulin resistance these are synonyms you know which would be indicated by low HDL high triglycerides but in people that don't have that if you will it have a triad that HDL is high the triglycerides are low the LDL spy doesn't seem at least in that analysis that that LDL is really even playing a role in it cardiovascular disease
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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there are probably two different phenotypes or I should phenotype is aware B's in medicine to mean like the external appearance of something there are probably two or three different disease states that go along with high LDL the traditionally high LDL is achieved through insulin resistance like you were saying the insulin insensitivity of an individual that is diabetes synonymous with diabetes so most people get high LDL with insulin resistant states and that is you see a low HDL and a high triglyceride when that happens that that phenotype that constellation of high LDL low HDL high triglycerides is essentially is associated what we call the metabolic syndrome or an insulin resistance state
maybe because if you if you isn't resistant may be having more LDL is bad because it does go into you know pain or pressure points in the in the circulation which are more damage and cause atherosclerosis there
just because you have a high ldl does not mean that there is a concentration based effect of that ldl getting pushed into the arterial wall there's something else going on i believe that something else is insulin resistance metabolic dysfunction
is it possible that in some situations in people who are insulin resistant the majority of the human population on the planet and in this country that elevated LDL sometimes looks worse or sometimes associates with higher rates of cardiovascular disease it's very possible that that is the actual situation that is going on
that not all LDL is the same. And when you look at things like insulin resistance and inflammation, it predicts, it tells you who LDL is problematic for and who it isn't.