The insulin signaling pathway involves PGC-1α, IRS1, PI3K, and GLUT4, and is responsible for bringing glucose into cells and activates nitric oxide synthase, generating nitric oxide and leading to vasodilation.

“bring the glucose in the cell in other words if people don't want to get mired down in this which is totally understandable insulin hits a receptor that receptor kicks off a Cascade that ultimately results in a little tube being like a little straw that goes into the cell surface that allows glucose to freely flow in against its in in its gradient but remember that same pathway also activates nitric oxide synthes that's right generates nitric oxide and that's why we see in patients with insulin resistance even if glucose is controlled cardiovascular disease is still up a very important yeah very important Point um so back to ose yeah so so so now what does it do uh it activates that siging pathway you generate nitric oxide now you vasod dilate that's why the blood pressure drops when you vasod dilate”