The Framingham study shows increased coronary artery disease risk with higher LDL, which is altered when stratifying by ApoA1.

“this is the Framingham study so this is an epidemiology study and we're looking at CA D risk by LDL that looks scary increased risk of coronary artery disease increasing risk of LDL but this is just all comers in the Framingham risk study what if we then stratify this and incorporate something like what dr. Wolfson is suggesting here what if we look at the AOA which is the HDL which is the April of a protein HDL and we stratify this look at how different these curves look when we take a look at the HDL relative to the LDL”