Peter Attia· MD
we have overwhelming evidence that LDL is a causal factor in atherosclerosis we have data from observational studies from genetic studies from Interventional trials it meets all the criteria for a causal Factor
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we have overwhelming evidence that LDL is a causal factor in atherosclerosis we have data from observational studies from genetic studies from Interventional trials it meets all the criteria for a causal Factor
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I mean like you have the mechanism the penetration of the IND it's very clear that that happens we have the animal models that show linear dose independent effects you have the mellan randomization and you have the clinical trials in humans it's and you have the prospective cohort studies and then you have the you have the genetic studies so right you have the pcsk9 over and under expressors so so