Peter Attia· MD
dramatically cut saturated fat which will uh do two things it will reduce cholesterol synthesis and it will reduce the liver's need to keep fat out of the liver by well so it's easier to describe it the other way in a high saturated fat diet what typically happens in addition to an increase in cholesterol synthesis is the liver suit through something called the sterile regulatory binding protein um says I don't need any more fat brought in I don't need any more cholesterol brought in so it down regulates LDL receptors so it pulls fewer LDL out of circulation and LDL will Skyrocket so the reverse is true if you cut saturated fat the liver is going to want more LDL coming in it will upregulate LDL receptors and pull more LDL out of circulation