Familial hypercholesterolemia patients with high LDL in the mid-19th century lived longer than the general population, suggesting a protective role during a time of high infectious disease mortality.

“what they found was in in the mid 19th century people with high LDL familiar lived a lot longer than the surrounding population around about 1980 10 20 that changed over so people with high LDL lived shorter and then it came back down again so there's foundation for this in part it's probably that during the 19th century the comments cause of death but human beings was infectious diseases let's kill them this was a thing to kill people this is the big scourge but from the he was like syphilis but he got to cutting he had in a bacterial infection that was it you were gone virtually before antibiotics these were real real think so”