PCSK9 is an acute phase reactant that increases in infection and inflammation to keep LDL in circulation and signal the body to increase receptors that clear injured LDL.

“in other words biologically the pcsk9 is an acute phase reactant what that means is that it goes up in the setting of infection and inflammation the reason it's doing that is because it says I need LDL to remain in circulation I'm going to downregulate The receptors in in which I pick up the LDL and cholesterol so that more LDL remains in circulation and at the same time it is giving signals to the body to increase the locks receptors The receptors that are designed to take away the injured LDL”