Mimicking the anabolic effects of leucine with synthetic compounds has not yielded dramatically better results than leucine itself.

“the sobering part was it's a small little pocket Lucine is a small molecule very small molecule and so it's not clear how you can mimic right the the immediate idea was hey can we mimic the anabolic effects of Lucine without taking Lucine can we make something better than Lucine and and we've managed to make things slightly better but nothing dramatically better and the structure tells you why because it's it basically is made to fit Lucine and nothing else”