Mice fed a high amount of branched-chain amino acids become hungrier, fatter, and die younger, but caloric restriction negates this lifespan reduction.

“if you give mice a lot of branched chain amino acids they are hungrier and they get fatter and they die younger which you might say wow that's you know the bad deed a lot of branch chain amino acids which you'll get from abundance of meat but what they found was if those mice then were calorically restrict or at least had their food intake restricted which we can do as conscious beings at which you do then it was fine it didn't reduce their lifespan”