Using single bacteriophages may be ineffective due to bacterial resistance, leading to the development of phage cocktails targeting bacteria through different mechanisms.

“Now, I told you before that bacteria as part of this arms race have developed very strong defense mechanisms against phages. So if you give just one phage, it is very likely that the bacteria it would attack would generate defense mechanisms that would make it resistant against this phage, and so your therapy would not be successful. So what we are doing, we are generating cocktails of phages that are targeting the same bacteria through different receptors or different mechanisms, and together these phages are killing the bacteria without allowing it”