Peter Attia· MD
PNC one doesn't just get turned on by Clarke restriction it's turned on by heat low amino acids salt high salt and so this is a gene that senses the environment and turns on the sirtuins
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
PNC one doesn't just get turned on by Clarke restriction it's turned on by heat low amino acids salt high salt and so this is a gene that senses the environment and turns on the sirtuins
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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we found the pnc one could mimic caloric restriction and raise nad or availability and if we knocked out the PNC one gene Yi cells didn't live longer when we calorie restricted them