The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
It turns out that all of us have some small amount of progerin, this protein in our systems. And I believe the evidence is that it increases somewhat as we age... Since we got our grant, there's a very interesting and, I think, quite important publication from Tom Misteli's group at the NIH showing that, in fact, Nrf2 is very intimately related to this process in progeria.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
what happens is that progerin, the sticky protein that I told you is on the inside of the nucleus, actually binds Nrf2 as it enters the nucleus to do its signaling thing and it gloms it up against the inside of the nucleus, so to speak