The high cost of ATP required to synthesize cholesterol suggests that preserving cholesterol via efficient LDL clearance would have been evolutionarily advantageous in resource-constrained environments.

“I just had never taken the additional leap of hey I know it takes 27 ATP to make a molecule of cholesterol but I never made the additional leap which was think about how expensive that is in in an environment that is so resource constraint which up until 150 years ago we were so we spent hundreds of millions of years in an environment where preservation of resources was the second priority only after reproduction”