Selecting sibling pairs discordant for acetaminophen exposure and autism outcome can introduce collider bias, falsely suggesting a 100% risk. — Whalespan
Selecting sibling pairs discordant for acetaminophen exposure and autism outcome can introduce collider bias, falsely suggesting a 100% risk.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
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High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“But this was not the case according to the Swedish study's senior author. And such a design would introduce what's known as a collider bias where the selection criteria create a situation where the exposure and outcome are already related in some way.”