Paul Saladino· MD
it's a marker and so you can see it come on
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's a marker and so you can see it come on
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and what we found was that by raising the levels of nad the fuel for the enzyme park that we could restore the activity of our DNA repair
when part goes to make these tails or these flags on the DNA it takes nad nicotinamide adenine dinucleotide and CLIA the the nicotinamide molecule is cleaved off and you get these ADP ribose chains
Our bodies are actually destroying an ad through carps and sirtuins and they're then they're recycling it back from nicotinamide all the time it's called the NAD salvage pathway
parp 1 is the one that's most studied and most important for this topic and it's a dna repair facilitator and it will go to a broken dna molecule and tell the rest of the proteins this is a problem come fix this it's a marker
its activity goes down with age coincident and probably caused by lower levels of nad as as the animals got older and what we found was that by raising the levels of nad the fuel for the enzyme park that we could restore the activity of dna repair