Peter Attia· MD
one of the most robust findings in mice is that if you somehow disable growth hormone activity the mice stay healthy and live a lot longer
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
one of the most robust findings in mice is that if you somehow disable growth hormone activity the mice stay healthy and live a lot longer
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now it's important to understand though that with one exception those studies are all cases where the animals are growth hormone signaling deficient through development so they are very very small animals and then they have constitutively low levels of signaling through that pathway for the rest of their life
So, if you take a mouse and you knock out the growth hormone receptor, this mouse will live 40%, 50% longer. It's also, and in spite, and this is work by John Kopchick and Andre Barkey, and in spite of living longer, it has much less diseases. So, almost half of these mice will get to the end of life with no diseases that are visible right?
Well, we knew from mice, from the work of John Kopchick and Andrzej Bartke, that mice that have either a growth hormone receptor, or growth hormone deficiency, live longer, about 40% longer, they also live much healthier.