Peter Attia· MD
So PI3 kinase stands for phosphoinositide 3 kinase. And the 3 means that it phosphorylates the 3 position on the inositol ring, which is the head group of this lipid.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So PI3 kinase stands for phosphoinositide 3 kinase. And the 3 means that it phosphorylates the 3 position on the inositol ring, which is the head group of this lipid.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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PI3 counties could phosphorylate the 3 position whether or not the 4 or 5 were already phosphorylated. So we now, that generated three new species, PI3P, PI3-4, and PI3-4-5.