Healthspan in worms can be assessed by measuring changes in behavior, tissue changes, and resistance to stress over time.

“Well, you know, that's a big debate right now is how to do that. Of course, the worms are changing their behaviors as they age, they're becoming slower, they're eating less, they cease reproduction. Eventually, they become paralyzed, essentially not moving at all in the plate. So there's plenty of things to look at. Also, their tissues are changing and you can look at the tissues themselves, and really we're just kind of sorting out what the best parameters might be right now.”