Sirtuins are enzymes that regulate genes and perform cellular functions including DNA repair, telomere maintenance, mitochondrial health, and inflammation control.

“the saturns um an analogy would be that they're the traffic cop in the cell they do regulate genes as silencers but they do other things in our bodies they've evolved to do many more things they control proteins that are involved in dna repair including parp the telomeres the mitochondria inflammation”

“these are little pacman that go around and they carry out a really interesting type of reaction they grab nad they will now donate the adenine ribose to the protein that they're targeting and typically at least for enzymes number one seven and six they target the histone proteins now histones are the packaging proteins for dna that bundle up the dna and uh typically involved in switching off genes”

“when nad levels are high the sirtuins can be active is that correct yeah and when when we say the sirtuins are active that means they're doing their job at the epigenetic at the genomic level at the histones is that what we mean when we say active”

“so the sirtuins they're de-acylases and and they've been called d acetylases but yeah as you as i've heard you talk about another podcast they're actually de-acelasis which is a larger group so they're pulling off groups”

“nad is required to activate signaling proteins known as sirtuins which are highly conserved enzymes that play roles in health span and longevity in multiple organisms sirtuins are linked to the regulation of a variety metabolic processes like the response to stress and the modulation of lifespan the way they do this is through epigenetic regulation”

“Sirtuins utilize nad to remove specific chemical structures called acetyl groups a process called deacetylation from cellular proteins to control the activation of genes involved in energy metabolism at AA fuji circadian rhythm DNA repair cell survival and more”