For high-grade prostate cancer, a PSMA PET scan is the most sensitive and specific imaging modality to determine the extent of disease.

“the thing that you need to do the one key thing is to do a pet psma scan psma is a prostate specific antigen prostate specific membrane antigen spef particularly that is enriched in its expression in prostate cancer cells and it is the most uh sensitive and specific way to determine the extent of a person who has high-grade prostate cancer disease so you need to Stage them so in other words it's a pet scan but instead of using fdg it uses PSM specific radial Lian because prostate tumors are not fdg Avid”