The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
i asked them what is 17 how fester dialed is it anywhere does it do anything and they all said good question i don't know so i know nothing about it but they should know something about it and apparently it's distinctly under investigated
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
what it binds to in which cells in which tissues what it's turning on biochemically is at this point quite obscure
so it's doing something it's got to be binding to something but it it probably is not the traditional estrogen receptors or it might be that plus something else to get um an effect on estrogen sensitive tissues
there at least two Labs that I know of Mike Stouts I think Mike is now in Oklahoma and um my former student Mariana sersi Mariana is at Wayne State they've published some really nice papers getting at the issue of what a 17 Alpha estral actually doing physiologically what does it bind to Mariana her last three papers and her just awarded Grant are focused on what 7 Al estral does in the brain what it does to estrogen sensitive and estrogen insensitive parts of the brain so there are a small number of labs I wish there were more that are diving into that question what is the target what is the receptor what is the physic ological effect and the more people that work on that I think the happier we will be