The proteins responsible for meiosis and chromosome separation in females must function intact from fetal development through 30-40 years of reproductive life.

“for women has been proteins that are responsible as I said in terms of meiosis and separating of the chromosomes and being able to have if you remember when meiosis started in females it actually is starting way way early in gestation so even during fetal life and so those proteins have to be working in intact from before a fetus is you know even born before a child is born lasting all the way through whenever that you know pregnancy is conceived essentially when those gametes are finally dividing so that could be you know 30 40 or more years for that process to have to work and that's kind of asking a lot when you think about the biology”