Luminal type prostate tumors are exquisitely sensitive to testosterone suppression and less likely to metastasize compared to basal cell tumors.

“so this is kind of a great tragedy it means that the cancers the prostate cancers that are most likely to kill you which by definition are the ones that spread are also the most capable of thriving in a low testosterone environment and therefore are least hurt by Androgen deprivation yes”

“if you look which we've done wow the distribution of a luminal differentiated tumor in a localized state is about 40% okay if you look at how many metastic lesions so you take tumors that are metastatic it's only it's less than 10% are luminal differentiated because they they just don't have the capacity to survive and spread to other parts of the body whereas a basil tumor which is by nature able to survive in the absence of testosterone and or uses alternate growth Pathways to testosterone because it doesn't have it it's not it's not dependent on it those tumors are more capable of spreading to other parts of the body”

“because it's it's if it if think about is on the basil side no if it's a luminal if it's a luminal type tumor think about it it's more dependent on that testosterone Rich micro environment with the DHT around it doesn't do as well theoretically living in the bone marrow when it metastasizes to the Bone or in the lymph nodes”