Peter Attia· MD
the animals also contained a mutation where they made less far less of a protein called bub r1 which is an Anna phase checkpoint protein so this is a protein that makes sure that your chromosomes line up on the spindle and it sort of is like a bit of a schoolmaster and it sort of says you're not dividing until everything's lined up and so if you don't have Bob r1 you just blow right through the checkpoint and you become polyploid and yon Vander's in my other co-founder long-term collaborator he created this animal thinking this animal was going to get tons of cancer because he was a cancer researcher so let's just make sure we understand why that's the case if Bob r1 is there to make sure your spindles line up it means that you should not be able to divide until all your chromatin is perfectly aligned everything is in perfect tip-top order and you're ready to undergo mitosis that's right so if you take away your master a lot of faulty division should follow that's correct so yawns hypothesis is we either attenuate or knock out Bob r1 we should get a lot of cancer that's right okay what happened that wasn't what happened the animals were super polyploid meaning that they wound up with super weird numbers of chromosomes too many too few all that good stuff the animals aged quickly so the animals wound up full of senescence cells okay so there is something about become having very wrong numbers of chromosomes and all of the effects of that that caused the animals to be full of senescence cells and to age very rapidly have features of aging that were onset very rapidly and die so it accelerated the speed with which it's a record played but it didn't change the music in other words they didn't die sooner because they got cancer they just died sooner because they sped up their aging we don't know the answer to that so these animals are extremely sick animals so trying to make a larger statement I think it's too much to say with an animal like that of the whole record metaphor what I can say with I think conviction is that clearly a whole bunch of things that go along with being old happened very quickly in these animals and these animals die very quickly they look visibly old for me it was an experiment that suggested that it was consistent with the notion that the senescence cells were actually driving these features of aging