Fructose activates brain reward areas, is an energy source for primate ancestors and hunter-gatherer tribes, and is preferentially consumed in fruits and honey.

“I think that the idea that fructose activates an area of the brain linked with reward and seeking of certain behaviors suggests that fructose is not really vestigal for humans I mean it's like you said this is an energy source it's in a food that ancestors undoubtedly consumed it's in a food that all hunter gatherer tribes ever studied on the planet consume it's in a series of foods whether it's fruit or honey um preferentially consume and and so that to me is not super vestigal”