Misfolded proteins can disrupt protein half-life, leading to their accumulation and aggregation within cells, which is exacerbated with age.

“when they damage the proteins the proteins become misfolded they're not their threedimensional structure is screwed up and when they become misfolded this disrupts the protein halflife and what this ends up doing is that protein just kind of sits around inside of the cell longer than it's supposed to it's usually supposed to get you know be gotten rid of sooner and when it sits around inside of the cell it starts to aggregate with other proteins that have been misfolded so as we age we start to get these protein aggregates that are accumulate inside of our cells outside of our cells”