Peter Attia· MD
and then what we did was yes a different question was like what happens in an adult Mouse so in the newborn Mouse it's a very different situation because any newborn mammal they don't have any fat or no reserves and so when the Japanese group did the extraordinary thing of trying to force-feed these or thathe G deficient newborn animals then they didn't extend their survival very much that was this Yoshinori group this was the Burmese Ashima and the Komatsu group I believe and I think it was coming from those two labs so what happened in that experiment they discovered that the mice died shortly after birth and then they realised that well they suspected they had a metabolic problem and they weren't suckling because they were probably too ill to by the time they were it would have been able to so they force-fed them and that allowed them to live for 24 hours but they still died anyway and then are you able to induce an ATAR G knockout in an adult yes so that's what we did because we realized that the newborn animal is it's just too fragile too fragile they've known nutrient reserves and actually in setting of cancer we're thinking of you want to treat an adult with a tumor so what's happening an autopsy and a newborn animal isn't even relevant and so we engineered mice where we can take an adult Mouse and give the mice a chemical so that inner central autop of gene will be deleted throughout the entire animal so one day they're an adult Mouse with autophagy and then a few days later there are an adult Mouse with no etaf adji and these mice were very extraordinary they live for two to three months and then they died predominantly of neurodegeneration