Paul Saladino· MD
testosterone has this metabolite called dihydrotestosterone or dht and dht has a very strong relationship with male pattern hair loss in fact when you rewind to research from the 1940s hamilton this doctor observed in male castrates that men who were castrated before puberty whereby they'd see a 95 reduction in testosterone and presumably dht levels as a consequence since dht is a metabolite of testosterone those men were protected from developing male pattern hair loss later on in life and later on there were anecdotal pieces of evidence from this island in papua new guinea where these men over expressed with this genetic mutation called a type 2 5 alpha reductase deficiency and what it showed us is that it's not testosterone overall that's causing hair loss but rather these men with this very