Common epithelial cancers have low reactivity to checkpoint modulators due to insufficient mutagenic burden.

“but the common epithelial cancers that result in 90 of deaths in patients have very little reactivity against the checkpoint modulator so although they can be life-saving and very likely although it's been too soon curable for some cancer patients the overwhelming majority of cancer patients just do not respond to taking off the brakes because when you take off the brakes there's not a strong enough reaction to take to take advantage of”

“we know the antigens are there we know that t cells are there it should work and it can work and i believe it will work uh as the years go on and that's 100 percent of what i'm working on today and that is how to utilize these unique mutational reactivities to cause these solid common epithelial cancers that result in 90 of all cancer deaths how to get them to respond to immunotherapy”

“and about 80% of patients with the common epithelial cancers it turns out as a result of the research done in recent years do exist that can recognize the products of the mutations but the immune system against them is too small is not vigorous enough”