Peter Attia· MD
they're these are compartments in the cell that have a membrane things get in them and there's about 60 enzymes in that compartment that can basically annihilate anything break it down into single components like for for example proteins amino acids come out Polymers of sugars individual sugars come out and and that was fine but the critical experiment and the one that really changed everything for us is then Tim did a simple experiment he said well let me remove amino acids and look where mtor is and it turned out it wasn't on lomes anymore it went off the lome then he added amino acids and he had even little movies within minutes it went back to the lomes and so what that told us is that nutrients communicated to mtor and one of the things they did was move mtor to the surface of the lome and then we went on and we found the docking station so it turns out you can think of mtor as like this big ship and there's sort of this docking like a pier and when it gets there it sits on top of these proteins that hold it there and it turns out that those proteins are the ones that nutrients talk to and there's an entire set of proteins about I think I count to there's about 20 proteins involved in making that communication to drive mtor to the surface of the lome and and we could go into the details of this but it's it's probably a little bit uh too much but there's multiple large protein complexes that do that communication and and what I think that indicates and I've said this in talks you know it could have been simple right there could have been one protein binds an amino acid talks to EMP but it's not there's a lot of sort of protein real estate used to do this which tells you the cell cares about this so the question becomes which amino acids and and I have to say that that really that that was broken open not by us but by Joe avick he had a paper in JB JBC where he looked at amino acid regulation of mtor this was this is before the lomes he was looking at the activity of using S6 kyes and he basically found a couple amino acids that mattered he found Lucine you know a very common essential Branch chain amino acid an important component of of whey protein for example that people take Arginine a very basic amino acid technically not essential