Loss of function in genes like CTEP and PCSK9 is beneficial for longevity and healthspan.

“also a longevity Gene yes you don't need that you don't need pcsk9 the theory is is that we all went through the evolutionary funnel about 10 000 years ago during the last ice age there were very few humans alive especially in the north and they went through the evolutionary funnel where everything was directed against being Thrifty people that could absorb the last calorie out of a mammoth were favored and actually we now think that those genes that we selected during that evolutionary funnel are now bad for us like we don't need pcsk9 we don't need CTP”