Paul Saladino· MD
turning on these other genes when they move so these come on now is a stress response a survival response that stops the cell dividing and changes metabolism so that they survive long enough for this repair to happen
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
turning on these other genes when they move so these come on now is a stress response a survival response that stops the cell dividing and changes metabolism so that they survive long enough for this repair to happen
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So the first thing that happens is gamma-H2AX gets lit up on the break and then within seconds, SIRT1 brings in HDAC1, helps remodel the DNA in the chromatin so that it's ready for the repair proteins to come in and without SIRT1 getting there, these other repair proteins are very inefficient...
Well, they're one of the first proteins to get to a broken chromosome.