Empirical evidence in C. elegans and mice contradicts theoretical mathematical proofs that a single gene mutation could never extend lifespan.

“The funny thing is you know nature early in 1993 published a very early date detailed six-page paper by linda partridge and her colleagues proving that there could never be a single gene mutation that extended life lifespan aging was too complicated too many feedback circuits it could never ever be done and linda's paper was based was was a statement of any species it wasn't explicitly stated but it was a theoretical proof that you could never have a single gene mutating that extended lifespan absolute mathematical proof lots of equations i could couldn't follow that it can't follow now so about six months later cynthia's paper came out saying hey look here's a gene that does that”