Upstream factors, not the regulation of mTOR levels themselves, are the primary critical regulatory input for pathway fine-tuning.

“now those right exactly some of the most important proteins in the cell so what what we have found now and I think others would agree is that regulation of mtor levels itself is is doesn't happen that much it does but it's not the critical regulatory input it's all the Upstream stuff and the regulation of that that really is where the pathway gets fine-tuned in different cells to different inputs”