Rhonda Patrick· PhD
Antibody-dependent enhancement also happens in SARS-CoV-1, but it did not result in more viral entry. Rather it caused activation of immune cells and immune induced pathology.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Antibody-dependent enhancement also happens in SARS-CoV-1, but it did not result in more viral entry. Rather it caused activation of immune cells and immune induced pathology.
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This was shown to occur in nonhuman primates given a vaccine against the SARS-CoV-1 spike IgG.
This is a real concern since antibody-dependent enhancement has been shown to occur with other coronaviruses, such as SARS-CoV-1 and MERS-CoV.